MK-677 (Ibutamoren)

MODERATE EVIDENCE

PEPTIDESmuscle growthsleepfat loss

An oral growth hormone secretagogue that mimics ghrelin, stimulating sustained GH release without injections.

How It Works

Binds to ghrelin receptors (GHSR) in the brain, triggering growth hormone release from the pituitary. Unlike peptide GH secretagogues, it's orally active.

Benefits

✓Increased growth hormone and IGF-1 levels
✓Improved sleep quality (deeper sleep)
✓Enhanced muscle recovery
✓Potential fat loss support
✓No injections required

Potential Side Effects

⚠Increased appetite (significant)
⚠Water retention and bloating
⚠Lethargy in some users
⚠Potential blood sugar elevation
⚠Numbness/tingling in extremities

FDA Status

Not FDA-approved; investigated but never completed approval process

Clinical Evidence

Human trials showed significant GH and IGF-1 elevation. Sleep quality improvements well-documented. Long-term safety data limited.

Common Dosage

10-25mg daily, typically before bed

⚠ Always consult with a healthcare professional before starting any new supplement or treatment.

Related Products

CJC-1295

A GHRH analog (Growth Hormone Releasing Hormone) that stimulates the pituitary gland to release growth hormone in pulses.

Ipamorelin

A GHRP analog that stimulates growth hormone release via ghrelin receptors, often paired with CJC-1295.

Medical Disclaimer

The information provided on this page is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any new treatment, supplement, or making changes to your health regimen.